833 research outputs found
SAGE: Sequential Attribute Generator for Analyzing Glioblastomas using Limited Dataset
While deep learning approaches have shown remarkable performance in many
imaging tasks, most of these methods rely on availability of large quantities
of data. Medical image data, however, is scarce and fragmented. Generative
Adversarial Networks (GANs) have recently been very effective in handling such
datasets by generating more data. If the datasets are very small, however, GANs
cannot learn the data distribution properly, resulting in less diverse or
low-quality results. One such limited dataset is that for the concurrent gain
of 19 and 20 chromosomes (19/20 co-gain), a mutation with positive prognostic
value in Glioblastomas (GBM). In this paper, we detect imaging biomarkers for
the mutation to streamline the extensive and invasive prognosis pipeline. Since
this mutation is relatively rare, i.e. small dataset, we propose a novel
generative framework - the Sequential Attribute GEnerator (SAGE), that
generates detailed tumor imaging features while learning from a limited
dataset. Experiments show that not only does SAGE generate high quality tumors
when compared to standard Deep Convolutional GAN (DC-GAN) and Wasserstein GAN
with Gradient Penalty (WGAN-GP), it also captures the imaging biomarkers
accurately
Mersenne Primes, Polygonal Anomalies and String Theory Classification
It is pointed out that the Mersenne primes and associated
perfect numbers play a significant role in string
theory; this observation may suggest a classification of consistent string
theories.Comment: 10 pages LaTe
Evolution and implementation of radiographic response criteria in neuro-oncology
Radiographic response assessment in neuro-oncology is critical in clinical practice and trials. Conventional criteria, such as the MacDonald and response assessment in neuro-oncology (RANO) criteria, rely on bidimensional (2D) measurements of a single tumor cross-section. Although RANO criteria are established for response assessment in clinical trials, there is a critical need to address the complexity of brain tumor treatment response with multiple new approaches being proposed. These include volumetric analysis of tumor compartments, structured MRI reporting systems like the Brain Tumor Reporting and Data System, and standardized approaches to advanced imaging techniques to distinguish tumor response from treatment effects. In this review, we discuss the strengths and limitations of different neuro-oncology response criteria and summarize current research findings on the role of novel response methods in neuro-oncology clinical trials and practice
Systematic Renormalization in Hamiltonian Light-Front Field Theory
We develop a systematic method for computing a renormalized light-front field
theory Hamiltonian that can lead to bound states that rapidly converge in an
expansion in free-particle Fock-space sectors. To accomplish this without
dropping any Fock sectors from the theory, and to regulate the Hamiltonian, we
suppress the matrix elements of the Hamiltonian between free-particle
Fock-space states that differ in free mass by more than a cutoff. The cutoff
violates a number of physical principles of the theory, and thus the
Hamiltonian is not just the canonical Hamiltonian with masses and couplings
redefined by renormalization. Instead, the Hamiltonian must be allowed to
contain all operators that are consistent with the unviolated physical
principles of the theory. We show that if we require the Hamiltonian to produce
cutoff-independent physical quantities and we require it to respect the
unviolated physical principles of the theory, then its matrix elements are
uniquely determined in terms of the fundamental parameters of the theory. This
method is designed to be applied to QCD, but for simplicity, we illustrate our
method by computing and analyzing second- and third-order matrix elements of
the Hamiltonian in massless phi-cubed theory in six dimensions.Comment: 47 pages, 6 figures; improved referencing, minor presentation change
Glueballs in a Hamiltonian Light-Front Approach to Pure-Glue QCD
We calculate a renormalized Hamiltonian for pure-glue QCD and diagonalize it.
The renormalization procedure is designed to produce a Hamiltonian that will
yield physical states that rapidly converge in an expansion in free-particle
Fock-space sectors. To make this possible, we use light-front field theory to
isolate vacuum effects, and we place a smooth cutoff on the Hamiltonian to
force its free-state matrix elements to quickly decrease as the difference of
the free masses of the states increases. The cutoff violates a number of
physical principles of light-front pure-glue QCD, including Lorentz covariance
and gauge covariance. This means that the operators in the Hamiltonian are not
required to respect these physical principles. However, by requiring the
Hamiltonian to produce cutoff-independent physical quantities and by requiring
it to respect the unviolated physical principles of pure-glue QCD, we are able
to derive recursion relations that define the Hamiltonian to all orders in
perturbation theory in terms of the running coupling. We approximate all
physical states as two-gluon states, and use our recursion relations to
calculate to second order the part of the Hamiltonian that is required to
compute the spectrum. We diagonalize the Hamiltonian using basis-function
expansions for the gluons' color, spin, and momentum degrees of freedom. We
examine the sensitivity of our results to the cutoff and use them to analyze
the nonperturbative scale dependence of the coupling. We investigate the effect
of the dynamical rotational symmetry of light-front field theory on the
rotational degeneracies of the spectrum and compare the spectrum to recent
lattice results. Finally, we examine our wave functions and analyze the various
sources of error in our calculation.Comment: 75 pages, 17 figures, 1 tabl
Effects of Thyroxine Exposure on Osteogenesis in Mouse Calvarial Pre-Osteoblasts
The incidence of craniosynostosis is one in every 1,800-2500 births. The gene-environment model proposes that if a genetic predisposition is coupled with environmental exposures, the effects can be multiplicative resulting in severely abnormal phenotypes. At present, very little is known about the role of gene-environment interactions in modulating craniosynostosis phenotypes, but prior evidence suggests a role for endocrine factors. Here we provide a report of the effects of thyroid hormone exposure on murine calvaria cells. Murine derived calvaria cells were exposed to critical doses of pharmaceutical thyroxine and analyzed after 3 and 7 days of treatment. Endpoint assays were designed to determine the effects of the hormone exposure on markers of osteogenesis and included, proliferation assay, quantitative ALP activity assay, targeted qPCR for mRNA expression of Runx2, Alp, Ocn, and Twist1, genechip array for 28,853 targets, and targeted osteogenic microarray with qPCR confirmations. Exposure to thyroxine stimulated the cells to express ALP in a dose dependent manner. There were no patterns of difference observed for proliferation. Targeted RNA expression data confirmed expression increases for Alp and Ocn at 7 days in culture. The genechip array suggests substantive expression differences for 46 gene targets and the targeted osteogenesis microarray indicated 23 targets with substantive differences. 11 gene targets were chosen for qPCR confirmation because of their known association with bone or craniosynostosis (Col2a1, Dmp1, Fgf1, 2, Igf1, Mmp9, Phex, Tnf, Htra1, Por, and Dcn). We confirmed substantive increases in mRNA for Phex, FGF1, 2, Tnf, Dmp1, Htra1, Por, Igf1 and Mmp9, and substantive decreases for Dcn. It appears thyroid hormone may exert its effects through increasing osteogenesis. Targets isolated suggest a possible interaction for those gene products associated with calvarial suture growth and homeostasis as well as craniosynostosis. © 2013 Cray et al
What determines growth potential and juvenile quality of farmed fish species?
Enhanced production of high quality and healthy fry is a key target for a successful and competitive expansion of the aquaculture industry. Although large quantities of fish larvae are produced, survival rates are often low or highly variable and growth potential is in most cases not fully exploited, indicating significant gaps in our knowledge concerning optimal nutritional and culture conditions. Understanding the mechanisms that control early development and muscle growth are critical for the identification of time windows in development that introduce growth variation, and improve the viability and quality of juveniles. This literature review of the current state of knowledge aims to provide a framework for a better understanding of fish skeletal muscle ontogeny, and its impact on larval and juvenile quality as broadly defined. It focuses on fundamental biological knowledge relevant to larval phenotype and quality and, in particular, on the factors affecting the development of skeletal muscle. It also discusses the available methodologies to assess growth and larvae/juvenile quality, identifies gaps in knowledge and suggests future research directions. The focus is primarily on the major farmed non-salmonid fish species in Europe that include gilthead sea bream, European sea bass, turbot, Atlantic cod, Senegalese sole and Atlantic halibut
Optimasi Portofolio Resiko Menggunakan Model Markowitz MVO Dikaitkan dengan Keterbatasan Manusia dalam Memprediksi Masa Depan dalam Perspektif Al-Qur`an
Risk portfolio on modern finance has become increasingly technical, requiring the use of sophisticated mathematical tools in both research and practice. Since companies cannot insure themselves completely against risk, as human incompetence in predicting the future precisely that written in Al-Quran surah Luqman verse 34, they have to manage it to yield an optimal portfolio. The objective here is to minimize the variance among all portfolios, or alternatively, to maximize expected return among all portfolios that has at least a certain expected return. Furthermore, this study focuses on optimizing risk portfolio so called Markowitz MVO (Mean-Variance Optimization). Some theoretical frameworks for analysis are arithmetic mean, geometric mean, variance, covariance, linear programming, and quadratic programming. Moreover, finding a minimum variance portfolio produces a convex quadratic programming, that is minimizing the objective function ðð¥with constraintsð ð 𥠥 ðandð´ð¥ = ð. The outcome of this research is the solution of optimal risk portofolio in some investments that could be finished smoothly using MATLAB R2007b software together with its graphic analysis
Search for heavy resonances decaying to two Higgs bosons in final states containing four b quarks
A search is presented for narrow heavy resonances X decaying into pairs of Higgs bosons (H) in proton-proton collisions collected by the CMS experiment at the LHC at root s = 8 TeV. The data correspond to an integrated luminosity of 19.7 fb(-1). The search considers HH resonances with masses between 1 and 3 TeV, having final states of two b quark pairs. Each Higgs boson is produced with large momentum, and the hadronization products of the pair of b quarks can usually be reconstructed as single large jets. The background from multijet and t (t) over bar events is significantly reduced by applying requirements related to the flavor of the jet, its mass, and its substructure. The signal would be identified as a peak on top of the dijet invariant mass spectrum of the remaining background events. No evidence is observed for such a signal. Upper limits obtained at 95 confidence level for the product of the production cross section and branching fraction sigma(gg -> X) B(X -> HH -> b (b) over barb (b) over bar) range from 10 to 1.5 fb for the mass of X from 1.15 to 2.0 TeV, significantly extending previous searches. For a warped extra dimension theory with amass scale Lambda(R) = 1 TeV, the data exclude radion scalar masses between 1.15 and 1.55 TeV
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